I fish there as often as I can. It's a little tricky and intimidating at first, but once you do some research, you'll be ok.
Look up some hatch charts, go to the South Holston Fly Shop and ask them some questions. They're a great resource. Their fly selections are targeted to SOHO and they can point you in the right direction.
And I'd also say go long leaders, 6x-7x tippets (2#). Go to TN Fish and Game site for a river map and buy a Delorme road map. Beyond that, you've got 8 miles of the best water out there. Just don't expect it to be a secret. The word has been out and you'll have others around.