Re: colorado trip
If it were me, I would head straight north to Colorado Springs, hang a left to the south platte for day one, then spend the night in Frisco. Get up the next morning and either fish the Colorado, Blue or Gore. Head west and hit the frying pan or roaring fork day three. Day 4 depends on how far you want to drive to get home. You could go south to durango, a bit further west to the Gunnison but I would head back east and hit the Arkansas. That brings you back into the CoSprings area...and you just turn south and head home.
Of course this all depends on time of year...but those are pretty good starts.