That's a lot of spools!
I've been experimenting with tying tapered leaders again, but if my goal is to carry the most minimal amount of gear I'd just take a spool of 4# maxima or vanish and just be done with it.
I carry only 1 fly box, with an assortment of mostly streamers -- buggers, carp flies, etc. and some foam bugs and soft hackles to cover most species I target (panfish/bass/brook trout). I leave extra fly boxes behind the seat of my truck in case I lose a fly box out there -- which is bound to happen