I thought we were talking about dry flies here....don't know why....
For nymphs and streamers, I fish all directions: up, down, across and down. If I could figure out how to do across and up, I'd do that as well.
Actually, I do have a fly drift down into an eddy whose current moves back up a bit, and let that action play out if it seems it might work.
One of my most successful techniques on the Schuylkill River, was to position myself near a channel I knew held smallmouth, cast downstream with a Clouser minnow, and then strip the line back up along the length of the channel. Very effective, especially since these channels tended to be rather narrow.
With dry flies, I tend to cast upstream, sometimes directly, and sometimes up and across. Last month I finally decided to target specific rising trout, and that has carried over to my panfish dry fly fishing. Much more rewarding, at least for me.