I often throw tiny flies for big trout. This past month we have been crushing big browns during the Trico Hatch. I have been using flies sized from 20ís, 22ís, 24ís. I use 5X when I can. (it fits the hook eye). I have become a fan of the 5.5x From Trout hunter as well. I agree that you want to use the largest Tippet possible. Years ago, I played the game of using very small tippets 6x, 7x and sometimes 8x. Yes, I landed some great fish, but I also lost many. The past few years I have been upping my tippet size. I often fish 5x and land these big browns all day long. Now, the water I am fishing is not crazy fast current, so I am basically fighting the fish only. (not fish and fast current). Specifically, this last season, I used lots of 4x tippet on dries. I have been impressed with the hook up and landed fish ratio. I have not experienced a drop off in takes using the 4x tippet.
This is my rule of thumb for my local waters. If fishing fast currents I use 4x & 5x to help turn the fish. If I am fishing slower currents but with Big Fish, I use 5x and 5.5x most often. https://www.cutthroatfurledleaders.c...et-detail.html
This is only my opinion and many others will have thoughts of their own, but I believe if you get a good presentation, with a good drift and proper mending, the larger tippet size will not spoke fish. There have been a few decent studies done, showing fish taking dry flies on very heavy tippets when the fly and tippet were simply free flowing down river (not attached to a rod & line). This tells us that when a proper drift is created, the tippet size has little effect.
I will admit that heavier (stiffer / stouter) tippet is more difficult to get a perfect presentations, but it can be done. Best of luck.