Honestly, I LOVE Orvis compartment fly boxes. I love that I can change the size of the compartments, easy to see through, and rubber o ring sealed for water resistance. They're simple, don't cost much, durable, doesnt crush dries, dont worry about torn foam, etc etc
Only thing I own that's Orvis, but I own a lot of them.
PS. Just make sure not to tip them while on the stream. Hasn't happened yet, knock on wood....
I'm with Okuma on Morrell fly boxes. They are the lightest you'll find, and they float, with a magnetic closure that can be opened one-handed. Since they're foam, it's not too difficult to tie a lanyard to them in case you drop them.
I also like the Cliff's Days Worth for my smaller nymphs and midges. One side has six magnetically-floored compartments, which work great for tiny flies, particularly on a windy day.
My third favorite box is the C&F Midge, which comes with threaders that are extremely helpful with these tiny flies.
The Scientific Anglers double-sided box is well designed, but too bulky for my vest. In fact, I've got one I've never used for that reason (but maybe if I lost some weight, it would ).
As you can see everyone has a preference and that preference has no common ground.
So I recommend you ask yourself a couple of questions and then look at everyones pictures and do some investigating on your own.
One, Are your fingers on the big side or small side. the boxes with slit foam puts the flies very close together.
Two, When your hands are cold - how well can you feel and manipulate the flies you tie on your tippet. Pick boxes that you can easily retrieve your flies from and put your flies up. Is having it tied to you a concern - else it can fall out of a pocket and be gone forever.
Three, Are the flies you fish with on the larger side or smaller side. I fish with files that range from size 20 to size 4 hooks, the midges and streamers reside in separate boxes. Soft hackles sowbugs and midges reside in an Orvis box in little bins in mixed groups - I dig around to find the one I want. You may be an organization person and want all your flies in organized rows - digging around may be unacceptable to you the style needs to fit your personality.
Four, if you are going to keep up with multiple boxes on the stream what are your size limits on carrying these boxes on stream. Where are you going to carry them. I use an over the shoulder bag that I swing to the back when not in use to hold boxes I am not using.
So look at what the pictures represent, evaluate what you want the box to do for you, go and touch the ones that interest you.
Just as a note - I hate the wheatley's with the clips and the spring doors. As you can see they look very cool and it's a very popular box. I gave mine away to kids on the river that needed some type of fly box. They were very happy and I was happy for them. But I was never going to use them again.
I like the little Flambeu's for midges - the cliffs bugger barn for buggers, and the Orvis box with spring doors, for nyphms, softhackles, sowbugs, etc. your preferences will be uniquely your own. There isn't a single perfect box.