Pretty much the majority of my pike fishing is done on hyper-oligotrophic water (almost sterile clean). While dabluz has a point that relates to a predator response mechanism, IF you are in waters with 10 pound+ pike....not much tends to faze them at that size....unless of course, there is also HUGE angling pressure.
IF you enter the waters calmly...do not make a huge fuss in casting...in time, you will see the pike 'return' to normal and move ever closer. Ticket now..to induce a strike.
I am a huge fan of weighted marabou leaches for pike. Simple to tie and if you forgo actual weighting of the fly itself and go to afixing a small split shot at the head of the fly on the leader instead, you can get tying down to about 2-3 minutes per fly....its that simple. And for that toothy predator, you don't want to spend a lot of time making pretty flies when typically, they (the flies) have a short life span either because bite offs or being chewed apart.
I typically run full floating line...and long(er) leader/tippets combos (10'+...adjusted for wading waters). I DO NOT use any form of wire leader...even for big pike but DO use heavier mono as tippet.
Back to flies....marabou leaches....maybe a pinch of flash-a-boo for sparkle. My fav colours are yellow, purple or black. Strip retrieve...2-3" strips on the return....pausing a second or 2 between strips. I find if I have a chaser...or a particularly 'fishing' feeling retrieve...I'll send back and increase the pause BUT strip faster. Remember, pike are AMBUSH predators so think like a dumb prey species that is minding its own business, darting to eat ITS own food....OR one that has suddenly become 'aware' something that could eat 'you' is near.
Be wary at the end of your retrieve....LOTS of time...I have seen a large pike rocket out of the water chasing the fly as it leaves right before you start to cast again. I have seen grown men scream as a snot rocket leaps into their laps.
One other 'rule' for me...if you're not snagging, you're not catching pike. Which is to say...ya gotta get down...and another reason for not spending too much time making pretty flies.
I have also had good luck...and fun using deer hair mice but find that works best when you can either wade out and cast back to shore (best later in the evening) or cast to structure. Pike 'on the dry', is the best for me....outdoing almost any other species and type of fishing.
I typically DON'T fly cast from boats (for pike). I will, however, boat to a location...and get out to wade though (see my talk above about fish jumping into my lap).
In closing of my dissertation on pike....I've never met a pike I didn't like.
King Joe, Outa Here!