We could probably stretch this thread a ways....
After seeing many fish come off of clients, as well as my own line,
I have learned to exterminate my habitual, (classic) straight up set.
The very slow (save the queen) sweep-set down stream is the start,
then keeping the rod at an angle (45 deg) to them helps greatly.
If they change direction you need to change too, maintaining the angle (Always opposite).
The lift-set also brings them up out of the slow laminar flow on the bottom, into fast water near the surface. This set will often lead to a lip hook (outside), where the sweep set hooks the corner inside their mouth. The vertical set combined with the extra current pressure makes it easy for them to shake free, or break off.
Very large fish, on very small flies, is the high bar setting.
If you do hook solidly, don't apply heavy pressure, just become their shadow, break their fishy will, not your leader, or the hook..
Tying sparsely on an over-sized/gape hook is a good strategy too.
Catching a heavy fish, in heavy water, on small stuff,
makes me as happy as a first time fisherman hooking up..
The Pit River, is the only water I absolutely use a wading staff on. Beautiful, fishy, but treacherous!
Not to mention poison oak, and rattlers too.
Jim