Depends on what you mean by large. Most flies that I used were at least 4" long. Stripers are opportunists, aren't usually picky, but can show preferences at times.
I agree with everything that Rip said, and the flies he & ejsell suggested are what I used most. As Rip said, it's best to try to match the local forage in profile & length, and somewhat close in color. Although, they'll take attractor flies too sometimes. Chartreuse is usually a good bet, and particularly in combinations with some other colors. Chart./white, chart./pink, chart./ yellow, etc. Black & purple is sometimes a good color combination. Not a bad idea to have a range of colors from light to dark, with most intending to match natural forage, at least generically. The light to dark variety will help with both light conditions & water clarity.
My most used, most successful colors are white, black, and chartreuse. I tie baitfish patterns often in gray shades, shades of olive, tan, or black, all over white with varying amounts of flash. These can imitate various baitfish species no matter where I'm fishing.
I would add Seaducers, Flatwings, Half & Half's & Murdich Minnows to the list. Also some topwater flies: poppers, sliders and Gurglers. As Rip, said, match the hatch generally, and all these various styles of flies because of the materials used in them have some different motion & profile. I've even tied some, like the Seaducer or Deceivers with saddle or neck hackle in the tails, still the same basic fly, but each type of hackle has a slightly different action.
I like Half & Half's tied with hackle or rabbit strips in the tails. Again, each has a different look & movement.
If possible, as the rods you may have will limit the sizes you can cast, have some variety too for the sizes. It's great to have 10 different fly patterns or styles, but if they're all the same size that too very much limits your possibilities. Flies in the 3" to 8" range are very common for Stripers.
Basically, larger flies that will allow you to cover the water column top to bottom and generically match the local forage is all you need.
